{"id":3218,"date":"2016-08-26T02:22:15","date_gmt":"2016-08-26T02:22:15","guid":{"rendered":"http:\/\/fkik.uin-malang.ac.id\/?p=3218"},"modified":"2026-03-26T03:39:42","modified_gmt":"2026-03-26T03:39:42","slug":"identification-of-protective-and-broadly-conserved-vaccine-antigens-from-the-genome-of-extraintestinal-pathogenic-escherichia-coli","status":"publish","type":"post","link":"https:\/\/fkik.uin-malang.ac.id\/zh\/identification-of-protective-and-broadly-conserved-vaccine-antigens-from-the-genome-of-extraintestinal-pathogenic-escherichia-coli\/","title":{"rendered":"\u4ece\u80a0\u5916\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\u57fa\u56e0\u7ec4\u4e2d\u9274\u5b9a\u4fdd\u62a4\u6027\u548c\u5e7f\u6cdb\u4fdd\u5b88\u7684\u75ab\u82d7\u6297\u539f"},"content":{"rendered":"<p><strong>Abdul Malik Setiawan\uff0c\u533b\u5b66\u535a\u58eb\uff0c\u611f\u67d3\u5b66\u7855\u58eb\u3002.<br \/>\n\u9a6c\u6717\u56fd\u7acb\u4f0a\u65af\u5170\u5927\u5b66\u6bdb\u62c9\u7eb3\u00b7\u9a6c\u5229\u514b\u00b7\u6613\u535c\u62c9\u6b23\u533b\u5b66\u9662\uff0c\u533b\u5b66\u4e0e\u5065\u5eb7\u79d1\u5b66\u5b66\u9662<\/strong><\/p>\n<p>\u5927\u80a0\u6746\u83cc\u662f\u4eba\u7c7b\u80a0\u9053\u4e2d\u6700\u5e38\u89c1\u7684\u5fae\u751f\u7269\u4e4b\u4e00\u3002\u867d\u7136\u5927\u591a\u6570\u5927\u80a0\u6746\u83cc\u83cc\u682a\u88ab\u8ba4\u4e3a\u662f\u5bbf\u4e3b\u7684\u6b63\u5e38\u83cc\u7fa4\uff0c\u4f46\u6709\u4e9b\u83cc\u682a\u5177\u6709\u81f4\u75c5\u80fd\u529b\u3002\u6839\u636e\u5176\u81f4\u75c5\u6027\uff0c\u8fd9\u4e9b\u83cc\u682a\u4e3b\u8981\u5206\u4e3a\u4e09\u7c7b\uff1a\u5171\u751f\u5927\u80a0\u6746\u83cc\u3001\u80a0\u9053\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\u548c\u80a0\u5916\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\uff08ExPEC\uff09(1)\u3002.<br \/>\n\u5927\u80a0\u6746\u83cc\u5916\u6e90\u6027\u81f4\u75c5\u83cc\uff08ExPEC\uff09\u80fd\u591f\u4fb5\u88ad\u5e76\u5b9a\u690d\u4e8e\u9664\u80c3\u80a0\u9053\u4ee5\u5916\u7684\u591a\u79cd\u4e0d\u540c\u90e8\u4f4d\uff0c\u8fd9\u88ab\u8ba4\u4e3a\u4f1a\u5bf9\u4eba\u4eec\u7684\u5065\u5eb7\u548c\u7ecf\u6d4e\u9020\u6210\u8bf8\u591a\u635f\u5bb3\uff082\uff09\u3002\u6b64\u5916\uff0c2000\u5e74\u4ee3\u8010\u836f\u6027ExPEC\u6570\u91cf\u7684\u589e\u52a0\u5f00\u59cb\u5f15\u8d77\u536b\u751f\u754c\u5bf9\u4eba\u7c7b\u62b5\u5fa1\u8fd9\u79cd\u75c5\u539f\u4f53\u91cd\u8981\u6027\u7684\u5e7f\u6cdb\u5173\u6ce8\uff083\uff09\u3002.<br \/>\n\u75ab\u82d7\u63a5\u79cd\u5df2\u88ab\u8bc1\u660e\u662f\u4fdd\u62a4\u4eba\u7c7b\u514d\u53d7\u5929\u82b1\u6216\u810a\u9ad3\u7070\u8d28\u708e\u7b49\u81f4\u547d\u4f20\u67d3\u75c5\u4fb5\u5bb3\u7684\u6700\u6709\u6548\u65b9\u6cd5\u3002\u6b64\u5916\uff0c\u5982\u4eca\u75ab\u82d7\u884c\u4e1a\u5206\u5b50\u6280\u672f\u7684\u8fdb\u6b65\u4e3a\u79d1\u5b66\u5bb6\u63d0\u4f9b\u4e86\u66f4\u591a\u673a\u4f1a\uff0c\u4ee5\u52a0\u5f3a\u9488\u5bf9\u5404\u79cd\u75be\u75c5\u7684\u75ab\u82d7\u7814\u53d1(4)\u3002\u5927\u80a0\u6746\u83cc\u5168\u57fa\u56e0\u7ec4\u5e8f\u5217\u7684\u83b7\u53d6\uff0c\u4f7f\u5f97\u901a\u8fc7\u7814\u7a76\u975e\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\u548c\u80a0\u5916\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\u4e4b\u95f4\u7684\u57fa\u56e0\u7ec4\u5dee\u5f02\uff0c\u53ef\u4ee5\u53d1\u73b0\u6f5c\u5728\u7684\u5019\u9009\u75ab\u82d7(1)\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5c1a\u65e0\u4efb\u4f55\u5019\u9009\u75ab\u82d7\u901a\u8fc7\u4e34\u5e8a\u8bd5\u9a8c\u3002\u672c\u6587\u5c06\u63a2\u8ba8\u79d1\u5b66\u5bb6\u5728\u80a0\u5916\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\uff08ExPEC\uff09\u75ab\u82d7\u7814\u53d1\u65b9\u9762\u6240\u505a\u7684\u5de5\u4f5c\u3002.<br \/>\nMoriel\u7b49\u4eba\uff082009\uff09\u5728\u5176\u7814\u7a76\u4e2d\uff0c\u5728\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\uff08ExPEC\uff09\u4e2d\u9274\u5b9a\u51fa19\u7ec4\u57fa\u56e0\uff0c\u8fd9\u4e9b\u57fa\u56e0\u4e5f\u88ab\u79f0\u4e3a\u201c\u57fa\u56e0\u7ec4\u5c9b\u201d\uff0c\u800c\u8fd9\u4e9b\u57fa\u56e0\u7ec4\u5c9b\u5728\u975e\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\u4e2d\u5e76\u4e0d\u5b58\u5728\u3002\u4ed6\u4eec\u5229\u7528\u201c\u51cf\u6cd5\u9006\u5411\u65b9\u6cd5\u201d\u4ece\u8fd9\u4e9b\u57fa\u56e0\u4e2d\u9884\u6d4b\u51fa230\u79cd\u6f5c\u5728\u7684\u75ab\u82d7\u5019\u9009\u6297\u539f\u3002\u8be5\u9884\u6d4b\u57fa\u4e8e\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\uff0c\u4ee5\u7b5b\u9009\u51fa\u8868\u9762\u76f8\u5173\u6216\u5206\u6ccc\u578b\u6297\u539f\u3002\u5728230\u79cd\u6297\u539f\u4e2d\uff0c\u67099\u79cd\u6297\u539f\u88ab\u8bc1\u5b9e\u5bf9\u611f\u67d3\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\u83cc\u682a\u7684\u5c0f\u9f20\u6a21\u578b\u5177\u6709\u4f53\u5185\u4fdd\u62a4\u4f5c\u7528\uff081\uff09\u3002.<br \/>\n\u4e5d\u79cd\u6297\u539f\u7684\u4fdd\u62a4\u6c34\u5e73\u4ece 13 % \u5230 82 % \u4e0d\u7b49\u3002\u5176\u4e2d\uff0cECOK1_3385 \u6297\u539f\u7684\u4fdd\u62a4\u6c34\u5e73\u6700\u9ad8\uff0882 %\uff09\uff0c\u4e14\u4fdd\u62a4\u6548\u679c\u6700\u4f73\u3002\u8be5\u6297\u539f\u968f\u540e\u88ab\u8bc1\u5b9e\u5bf9\u591a\u79cd\u80a0\u5916\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc (ExPEC) \u83cc\u682a\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\uff0c\u4fdd\u62a4\u6548\u529b\u8303\u56f4\u4ece 43% \u5230 78%\u3002\u4e3b\u52a8\u514d\u75ab\u548c\u88ab\u52a8\u514d\u75ab\u5747\u53ef\u6709\u6548\u9884\u9632\u83cc\u8840\u75c7\u548c\u6b7b\u4ea1\u3002Moriel \u7b49\u4eba\u8ba4\u4e3a\uff0cECOK1_3385 \u57fa\u56e0\u7f16\u7801\u7684\u6297\u539f\u662f\u4e00\u79cd\u5e7f\u8c31\u7684 ExPEC \u75ab\u82d7\u5019\u9009\u7269 (1)\u3002.<br \/>\nECOK1_3385\u57fa\u56e0\u7684\u72ec\u7279\u4e4b\u5904\u5728\u4e8e\uff0c\u5b83\u4e0d\u4ec5\u5e7f\u6cdb\u5206\u5e03\u4e8e\u80a0\u5916\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\uff08ExPEC\uff09\uff0c\u4e5f\u5e7f\u6cdb\u5206\u5e03\u4e8e\u80a0\u9053\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\uff08InPEC\uff09\u548c\u975e\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\u3002\u7136\u800c\uff0c\u7531\u4e8e\u975e\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\u57fa\u56e0\u7ec4\u4e2d\u7f3a\u4e4fT2SS\u533a\u57df\uff0c\u56e0\u6b64\u8be5\u6297\u539f\u4e0d\u4f1a\u5728\u975e\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\u4e2d\u5206\u6ccc\u3002T2SS\u533a\u57df\u53ef\u88ab\u89c6\u4e3a\u533a\u5206\u975e\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\u548c\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\u7684\u6bd2\u529b\u56e0\u5b50(1)\u3002\u56e0\u6b64\uff0c\u8be5\u6297\u539f\u4e0d\u4f1a\u8bf1\u5bfc\u5bbf\u4e3b\u5bf9\u4f5c\u4e3a\u6b63\u5e38\u4eba\u83cc\u7fa4\u7684\u975e\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\u4ea7\u751f\u514d\u75ab\u53cd\u5e94\u3002.<br \/>\nMoriel\u7b49\u4eba\u7814\u7a76\u4e2d\u7684\u201c\u53cd\u5411\u75ab\u82d7\u5b66\u201d\u65b9\u6cd5\u662f\u672c\u62a5\u544a\u5e94\u91cd\u70b9\u5f3a\u8c03\u7684\u90e8\u5206\u3002\u57fa\u56e0\u7ec4\u6280\u672f\u7684\u8fdb\u6b65\u6700\u7ec8\u5c06\u4e3a\u75ab\u82d7\u7814\u53d1\u5e26\u6765\u76ca\u5904\u3002\u9996\u4e2a\u91c7\u7528\u8be5\u65b9\u6cd5\u6210\u529f\u7814\u53d1\u7684\u5019\u9009\u75ab\u82d7\u662fB\u7fa4\u8111\u819c\u708e\u7403\u83cc\uff08MenB\uff09\u75ab\u82d7\u3002\u76ee\u524d\uff0c\u5176\u4ed6\u57fa\u4e8e\u57fa\u56e0\u7ec4\u7684\u65b9\u6cd5\uff0c\u4f8b\u5982\u6539\u8fdb\u7684\u53cd\u5411\u75ab\u82d7\u5b66\u3001\u8f6c\u5f55\u7ec4\u5b66\u3001\u529f\u80fd\u57fa\u56e0\u7ec4\u5b66\u548c\u86cb\u767d\u8d28\u7ec4\u5b66\uff0c\u4e5f\u88ab\u7528\u4e8e\u5f00\u53d1\u65b0\u578b\u5019\u9009\u75ab\u82d7\uff085\uff09\u3002\u6b64\u5916\uff0c\u751f\u7269\u4fe1\u606f\u5b66\u7684\u5174\u8d77\u4e3a\u57fa\u4e8e\u57fa\u56e0\u7ec4\u7684\u75ab\u82d7\u7814\u53d1\u63d0\u4f9b\u4e86\u4e00\u79cd\u5de5\u5177\uff0c\u5b83\u80fd\u591f\u5229\u7528\u7b80\u5355\u7684\u8ba1\u7b97\u6280\u672f\u6765\u9610\u660e\u5206\u5b50\u751f\u7269\u5b66\uff0c\u4e0e\u4f20\u7edf\u65b9\u6cd5\u76f8\u6bd4\uff0c\u53ef\u4ee5\u5b9e\u73b0\u66f4\u5feb\u7684\u75ab\u82d7\u751f\u4ea7\u3002.<\/p>\n<p>\u53c2\u8003\u5217\u8868<br \/>\n1. Moriel DG, Bertoldi I, Spagnuolo A, Marchi S, Rosini R, Nesta B, et al. \u4ece\u80a0\u5916\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\u57fa\u56e0\u7ec4\u4e2d\u9274\u5b9a\u51fa\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\u4e14\u5e7f\u6cdb\u4fdd\u5b88\u7684\u75ab\u82d7\u6297\u539f\u3002\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a\u30022010 \u5e74 5 \u6708 18 \u65e5\uff1b107(20):9072-7\u3002.<br \/>\n2. Smith JL, Fratamico PM, Gunther NW.\u80a0\u5916\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\u3002\u98df\u6e90\u6027\u75c5\u539f\u4f53\u548c\u75be\u75c5\u30022007;4(2):134-63\u3002.<br \/>\n3. JDD pitout. \u80a0\u5916\u81f4\u75c5\u6027\u5927\u80a0\u6746\u83cc\uff1a\u6297\u83cc\u836f\u7269\u8010\u836f\u6027\u3001\u5b9e\u9a8c\u5ba4\u8bca\u65ad\u548c\u6cbb\u7597\u7684\u6700\u65b0\u8fdb\u5c55\u3002\u300a\u6297\u611f\u67d3\u6cbb\u7597\u4e13\u5bb6\u8bc4\u8bba\u300b\u30022012 \u5e74 10 \u6708\uff1b10(10):1165-76\u3002PubMed PMID\uff1a1266802195\uff1b23199402\u3002.<br \/>\n4. Plotkin SA. \u75ab\u82d7\uff1a\u8fc7\u53bb\u3001\u73b0\u5728\u548c\u672a\u6765\u3002Nat Med. 2005 \u5e74 4 \u6708\uff1b11(4):S5-S11\u3002.<br \/>\n5. Rinaudo CD, Telford JL, Rappuoli R, Seib KL. \u57fa\u56e0\u7ec4\u65f6\u4ee3\u7684\u75ab\u82d7\u5b66\u3002\u4e34\u5e8a\u7814\u7a76\u6742\u5fd7\u30022009 \u5e74 9 \u6708\uff1b119(9):2515-25\u3002.<\/p>","protected":false},"excerpt":{"rendered":"<p>Abdul Malik Setiawan, M.D, M.Infect.Dis. School of Medicine, Faculty of Medicine and Health Sciences. State Islamic University Maulana Malik Ibrahim Malang One of the most common microorganisms founded in the human gut is Escherichia coli. While most strains of these microorganisms considered as a normal flora to the host, some strains have the ability to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3316,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[15,16,17],"class_list":["post-3218","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artikel","tag-antigen","tag-e-coli","tag-vaksin"],"_links":{"self":[{"href":"https:\/\/fkik.uin-malang.ac.id\/zh\/wp-json\/wp\/v2\/posts\/3218","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fkik.uin-malang.ac.id\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fkik.uin-malang.ac.id\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fkik.uin-malang.ac.id\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fkik.uin-malang.ac.id\/zh\/wp-json\/wp\/v2\/comments?post=3218"}],"version-history":[{"count":1,"href":"https:\/\/fkik.uin-malang.ac.id\/zh\/wp-json\/wp\/v2\/posts\/3218\/revisions"}],"predecessor-version":[{"id":16077,"href":"https:\/\/fkik.uin-malang.ac.id\/zh\/wp-json\/wp\/v2\/posts\/3218\/revisions\/16077"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fkik.uin-malang.ac.id\/zh\/wp-json\/wp\/v2\/media\/3316"}],"wp:attachment":[{"href":"https:\/\/fkik.uin-malang.ac.id\/zh\/wp-json\/wp\/v2\/media?parent=3218"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fkik.uin-malang.ac.id\/zh\/wp-json\/wp\/v2\/categories?post=3218"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fkik.uin-malang.ac.id\/zh\/wp-json\/wp\/v2\/tags?post=3218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}